Amarok is the music player for Linux and Unix with an intuitive interface. Amarok makes playing the music you love easier than ever before - and looks good doing it. (GPL)
Aqualung is an advanced music player originally targeted at the GNU/Linux operating system, today also running on FreeBSD, OpenBSD and Microsoft Windows. (GPL)
Ario is a GTK2 client for MPD (Music player daemon). The interface used to browse the library is inspired by Rhythmbox but Ario aims to be much lighter and faster. (GPL)
Decibel Audio Player is a GTK+ open-source audio player designed for GNU/Linux, which aims at being very straightforward to use by mean of a very clean and user friendly interface. (GPL)
GMPC is one of the oldest, longest maintained and the most full featured GUI mpd client. It can be easily exteneded using the many available plugins. (GPL)